The Plasmin Activity in Tear Film and Chronic Corneal Ulcer.
- Author:
Young Doo YOON
1
;
Hong Bok KIM
Author Information
1. Department of Ophthalmology, Yonsei University College of Medicine Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Plasmin
- MeSH:
Collagen;
Collagenases;
Cornea;
Corneal Ulcer*;
Fibrin;
Fibrinolysin*;
Hand;
Humans;
Plasma;
Plasminogen;
Plasminogen Activators;
Scleritis;
Tears*
- From:Journal of the Korean Ophthalmological Society
1991;32(10):844-849
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Plasmin is an enzyme which plays an important role in the inflammatory process by activating vasoactive amine and lysis of fibrin. On the other hand, plasmin is also known to activate latent collagenase. Plasmin is an activated form of plasminogen which is stimulated by the plasminogen activator that exists in plasma and tissue. Gordon et al(1980) insisted that collagenase is important to the formation of corneal ulcer because it destroys the collagen which is the main component of the cornea. Berman et al(1980) reported that corneal tissue destruction by plasminogen activator-plasmin system can be a cause of corneal ulcer. We could obtain the following results by checking the plasmin activity in the tear of chronic corneal ulcer patients and necrotizing scleritis patients. 1. The plasmin activity in the tear was increased in all three chronic corneal ulcer patients in concentration of 1/16 sigma unit/ml to 1/8 sigma unit/ml. 2. There was no plasmin activity in the tear of the two necrotizing scleritis patients.
