Ultra-Structural Changes of the Chorioretina Following Intra-Vitreal Injection of Ornithine in Rabbit.
- Author:
Byung Joo KIM
1
;
Yong Seok YOO
;
Jin Hyung YOO
Author Information
1. Department of Ophthalmology, Inje University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Chorioretina;
Electron microscopy;
Ornithine
- MeSH:
Animal Experimentation;
Atrophy;
Choroid;
Cytoplasm;
Epithelium;
Intravitreal Injections;
Melanocytes;
Microscopy, Electron;
Microvilli;
Mitochondria;
Ornithine*;
Phagosomes;
Rabbits;
Retina
- From:Journal of the Korean Ophthalmological Society
1991;32(10):878-883
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The ultrastructural changes of the chorioretina following the intravitreal injection of ornithine in rabbit eyes at 1,2,4,8 week time intervals were investigated employing electron microscopy in this animal experiment. 1. 1 week after injection, swelling of the mitochondria in the cytoplasm of the pigment epithelium was seen. 2. 2 weeks after injection, phagosomes and phagolysosomes were present in the cytoplasm of the pigment epithelium and nerve elements in the inner nuclear layer disappeared and were replaced by Muller cell. 3. 4 weeks after injection, stroma of the choroid was atrophied and abundant melanocytes were aggregated, and papillary formed pigment epithelium with detachment of the retina was seen. 4. 8 weeks after injection, stromal atrophy and attenuated choriocapillaries of the choroid were present, and proliferation of the microvilli of the pigment epithelium after detachment of the retina was seen. 5. In summary intravitreal injection of ornithine in rabbits initially caused marked changes in the pigment epithelium with subsequent degeneration of the choroid and sensory retina.
