Toxic Epidermal Necrolysis Induced by the Topical Carbonic Anhydrase Inhibitors Brinzolamide and Dorzolamide.
- Author:
Ji Sun CHUN
1
;
Sook Jung YUN
;
Jee Bum LEE
;
Seong Jin KIM
;
Young Ho WON
;
Seung Chul LEE
Author Information
- Publication Type:Case Report
- Keywords: Brinzolamide; Dorzolamide; Toxic epidermal necrolysis
- MeSH: Carbon; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Epidermal Necrolysis, Toxic; Intraocular Pressure; Ocular Hypertension; Stevens-Johnson Syndrome; Sulfonamides; Thiazines; Thiophenes
- From:Annals of Dermatology 2008;20(4):260-262
- CountryRepublic of Korea
- Language:English
- Abstract: Brinzolamide and dorzolamide are highly specific topical carbonic anhydrase inhibitors (CAIs). They lower intraocular pressure (IOP) by reducing the rate of aqueous humour formation without serious side effects. Although systemic CAIs are the most potent medications for lowering intraocular pressure for conditions with ocular hypertension, many cases with adverse systemic reactions have been reported, including Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN). Here, we report 2 cases of TEN that were associated with topical CAIs rather than systemic CAIs.
