Fetal Nuchal Translucency Measurement for Detection of Chromosomal Abnormalities in the First Trimester of High Risk Pregnancy.
- Author:
Ji Young LEE
;
Kyu Ha CHOI
;
Chan Woo PARK
;
Tae Suk YUN
;
Choo Jin PARK
;
Pong Rheem JANG
;
Yang Suh PARK
- Publication Type:Original Article
- Keywords:
Nuchal translucency;
Chromosomal abnormalities;
Ultrasound screening
- MeSH:
Amniocentesis;
Chromosome Aberrations*;
Female;
Fetus;
Follow-Up Studies;
Humans;
Nuchal Translucency Measurement*;
Pregnancy;
Pregnancy Trimester, First*;
Pregnancy, High-Risk*;
Prospective Studies;
Ultrasonography
- From:Korean Journal of Obstetrics and Gynecology
1998;41(11):2739-2742
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To determine the value of sonographic nuchal translucency measurement for the detection of chromosomal abnormalities in high risk pregnancies. METHOD: The feasibility of nuchal translucency was tested in a prospective study of 1260 pregnancies at 10- 13 weeks' gestation. RESULTS: The nuchal translucency of 3 mm or greater was identified in 41 fetuses (3.2%), 19 of whom proved subsequently by either amniocentesis or postnatal follow-up have chromosomal abnormalities. The sensitivity of nuchal translucency for chromosomal abnormalities was 82.6% (19 of 23 cases), the positive predictive value of nuchal translucency for chromosomal abnormalities detection was 46.3% (19 of 41 cases). CONCLUSION: The observed sensitivity, false-positive rate and predictive value suggest that sonographic nuchal translucency should be undertaken at 10 to 13 weeks of gestation.
