Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis.
- Author:
Yu Mi LEE
1
;
Sun Mi KIM
;
Su Jin PARK
;
Sang Oh LEE
;
Sang Ho CHOI
;
Yang Soo KIM
;
Jun Hee WOO
;
Sung Han KIM
Author Information
- Publication Type:Brief Communication
- Keywords: Interferon-gamma release assay; Tuberculosis; Miliary
- MeSH: Humans; Immunosuppression; Interferon-gamma Release Tests; Tuberculosis*
- From:Infection and Chemotherapy 2014;46(4):248-252
- CountryRepublic of Korea
- Language:English
- Abstract: Limited data are available on which factors are associated with strong immunologic responses to T-SPOT.TB. We investigated the factors associated with strong positive responses in patients with extrapulmonary tuberculosis (E-TB). Of 173 patients with E-TB who gave positive results on T-SPOT.TB, 26 (15%) with a strong positive response (defined as > or =1,000 spot-forming units (SFU)/2.5x10(5) PBMC to ESAT-6 or CFP-10) and 71 (41%) with a low positive response (< or = 99 SFU (6-99 SFU)/2.5x10(5) PBMC) were further analyzed. Miliary TB was independently associated with a strong positive response to T-SPOT.TB, while advanced age and immunosuppression were independently associated with weak positive T-SPOT.TB responses.
