Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation.
- Author:
Chang H KIM
1
,
2
,
3
;
Jeongho PARK
;
Myunghoo KIM
Author Information
- Publication Type:Review
- Keywords: Short-chain fatty acids; Th1; Th17; IL-10; FoxP3; Microbiota; Inflammation; Colitis; Microbial metabolites
- MeSH: Adaptive Immunity; Cell Differentiation; Colitis; Cues; Cytokines; Fatty Acids, Volatile*; Immune Tolerance; Inflammation*; Interleukin-10; Microbiota; Micronutrients; T-Lymphocytes*; T-Lymphocytes, Regulatory
- From:Immune Network 2014;14(6):277-288
- CountryRepublic of Korea
- Language:English
- Abstract: T cells are central players in the regulation of adaptive immunity and immune tolerance. In the periphery, T cell differentiation for maturation and effector function is regulated by a number of factors. Various factors such as antigens, co-stimulation signals, and cytokines regulate T cell differentiation into functionally specialized effector and regulatory T cells. Other factors such as nutrients, micronutrients, nuclear hormones and microbial products provide important environmental cues for T cell differentiation. A mounting body of evidence indicates that the microbial metabolites short-chain fatty acids (SCFAs) have profound effects on T cells and directly and indirectly regulate their differentiation. We review the current status of our understanding of SCFA functions in regulation of peripheral T cell activity and discuss their impact on tissue inflammation.
