Serotonin Transporter and COMT Polymorphisms as Independent Predictors of Health-related Quality of Life in Patients with Panic Disorder.
10.3346/jkms.2016.31.5.757
- Author:
Eunho KANG
1
;
Ah Young CHOE
;
Borah KIM
;
Jun Yeob LEE
;
Tai Kiu CHOI
;
Hae Ran NA
;
Sang Hyuk LEE
Author Information
1. Department of Psychiatry, Inwha Hospital, Pocheon, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Quality of Life;
Panic Disorder;
5-HTTLPR;
COMT Val(158)Met
- MeSH:
Adult;
Age Factors;
Alleles;
Case-Control Studies;
Catechol O-Methyltransferase/*genetics;
Female;
Genotype;
Humans;
Male;
Middle Aged;
Panic Disorder/genetics/*pathology;
Polymorphism, Single Nucleotide;
*Quality of Life;
Regression Analysis;
Serotonin Plasma Membrane Transport Proteins/*genetics;
Sex Factors
- From:Journal of Korean Medical Science
2016;31(5):757-763
- CountryRepublic of Korea
- Language:English
-
Abstract:
There is growing evidence of poor health-related quality of life (HRQOL) in patients with panic disorder (PD). However, little is known about the factors affecting HRQOL in patients with PD. The authors examined whether 5-HTTLPR tri-allelic approach and Cathechol-O-methyltransferase (COMT) Val(158)Met polymorphism can predict HRQOL in patients with PD controlling for sociodemographic factors and disorder-related symptom levels. The sample consisted of 179 patients with PD consecutively recruited from an outpatient clinic and age- and gender ratio-matched 110 healthy controls. The SF-36 was used to assess multiple domains of HRQOL. Hierarchical multiple regression analysis was performed to determine the independent effect of the 5-HTTLPR and COMT Val(158)Met on the SF-36 in panic patients. Patients with PD showed lowered HRQOL in all sub-domains of the SF-36 compared to healthy controls. The 5-HTTLPR independently and additively accounted for 2.2% of variation (6.7% of inherited variance) of perceived general health and the COMT Val(158)Met independently and additively accounted for 1.5% of variation (5.0% of inherited variance) of role limitation due to emotional problems in patient group. The present study suggests that specific genetic polymorphisms are associated with certain domains of HRQOL and provides a new insight on exploring the factors that predict HRQOL in patients with PD.
