Comparison of Efficacy of Cefoperazone/Sulbactam and Imipenem/Cilastatin for Treatment of Acinetobacter Bacteremia.
- Author:
Jun Yong CHOI
1
;
Chang Oh KIM
;
Yoon Seon PARK
;
Hee Jung YOON
;
So Youn SHIN
;
Young Keun KIM
;
Myung Soo KIM
;
Yeon A KIM
;
Young Goo SONG
;
Dongeun YONG
;
Kyungwon LEE
;
June Myung KIM
Author Information
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords: Acinetobacter; bacteremia; cefoperazone/sulbactam; imipenem/cilastatin
- MeSH: Sulbactam/*therapeutic use; Protease Inhibitors/therapeutic use; Middle Aged; Male; Imipenem/therapeutic use; Humans; Female; Drug Therapy, Combination; Drug Resistance, Bacterial; Cilastatin/therapeutic use; Cefoperazone/*therapeutic use; Bacteremia/*drug therapy; Anti-Bacterial Agents/*therapeutic use; Aged; Adult; Adolescent; Acinetobacter Infections/*drug therapy/mortality; Acinetobacter/drug effects/isolation & purification
- From:Yonsei Medical Journal 2006;47(1):63-69
- CountryRepublic of Korea
- Language:English
- Abstract: Multiple antibiotic reisistance threatens successful treatment of Acinetobacter baumannii infections worldwide. Increasing interest in the well-known activity of sulbactam against the genus Acinetobacter has been aroused. The purpose of this study was to compare the outcomes for patients with Acinetobacter bacteremia treated with cefoperazone/sulbactam versus imipenem/cilastatin. Forty-seven patients with Acinetobacter baumannii bacteremia were analyzed through a retrospective review of their medical records for antibiotic therapy and clinical outcome. Thirty-five patients were treated with cefoperazone/sulbactam, and twelve patients with imipenem/ cilastatin. The percentage of favorable response after 72 hours was not statistically different between cefoperazone/ sulbactam group and imipenem/ cilastatin group. The mortality rate was not statistically different, too. Cefoperazone/sulbactam was found to be as useful as imipenem/cilastatin for treating patients with Acinetobacter bacteremia.
