Effects of a safflower tea supplement on antioxidative status and bone markers in postmenopausal women.
- Author:
Sung Hee CHO
1
;
Jeong Hee JANG
;
Ji Young YOON
;
Chi Dong HAN
;
Youngsun CHOI
;
Sang Won CHOI
Author Information
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords: Safflower tea; postmenopausal women; antioxidant; bone marker
- MeSH: 4-Butyrolactone; alpha-Tocopherol; Ascorbic Acid; Bone Density; Carthamus tinctorius; Ethanol; Female; Genistein; Humans; Lignans; Liver; Osteocalcin; Phytoestrogens; Plasma; Polyphenols; Seeds; Serotonin; Tea; Thiobarbituric Acid Reactive Substances; Vitamin A; Vitamins
- From:Nutrition Research and Practice 2011;5(1):20-27
- CountryRepublic of Korea
- Language:English
- Abstract: We conducted this study to examine the effects of safflower seed granular tea containing physiologically active polyphenols on antioxidative activities and bone metabolism. Forty postmenopausal women ages 49 to 64-years were recruited from Daegu and Gyeongbuk and were randomly assigned to either a safflower tea supplement (Saf-tea) group (n = 27) or a placebo group (n = 13). The Saf-tea group received 20 g of safflower seed granule tea per day containing a 13% ethanol extract of defatted safflower seeds, whereas the placebo group received a similar type of tea that lacked the ethanol extract. No significant changes in nutrient intake for either the placebo or Saf-tea groups were observed before or after the study period, except vitamin A intake increased after 6 months in the Saf-tea group. Dietary phytoestrogen intakes were similar in the Saf-tea group (60.3 mg) and placebo group (52.5 mg). Significant increases in plasma genistein and enterolactone were observed in the Saf-tea group. After 6 months of supplementation, serum levels of antioxidant vitamins such as alpha-tocopherol and ascorbic acid increased significantly, and TBARS levels decreased in the Saf-tea group compared to the placebo group. Serum osteocalcin levels were reduced (P < 0.05) in the Saf-tea group after 6 months, whereas serum osteocalcin did not change in the placebo group. Urinary deoxypyridinoline/creatinine excretion was not different between the two groups at baseline, and did not change in either group after 6 months. Bone mineral density decreased significantly in the placebo group (P < 0.01) but not in the supplemented group. It was concluded that polyphenols (72 mg/day), including serotonin derivatives, in the Saf-tea had both antioxidant and potential bone protecting effects in postmenopausal women without liver toxicity.
