The First Successful Heart-Lung Transplant in a Korean Child with Humidifier Disinfectant-Associated Interstitial Lung Disease.
10.3346/jkms.2016.31.5.817
- Author:
Won Kyoung JHANG
1
;
Seong Jong PARK
;
Eun LEE
;
Song I YANG
;
Soo Jong HONG
;
Ju Hee SEO
;
Hyung Young KIM
;
Jeong Jun PARK
;
Tae Jin YUN
;
Hyeong Ryul KIM
;
Yong Hee KIM
;
Dong Kwan KIM
;
Seung Il PARK
;
Sang Oh LEE
;
Sang Bum HONG
;
Tae Sun SHIM
;
In Cheol CHOI
;
Jinho YU
Author Information
1. Department of Pediatrics, Asan Medical Center Children's Hospital, College of Medicine, University of Ulsan, Seoul, Korea. jyu3922@gmail.com
- Publication Type:Case Reports
- Keywords:
Heart-Lung Transplantation;
Extracorporeal Membrane Oxygenation;
Interstitial Lung Disease;
Inhalation Exposure
- MeSH:
Child, Preschool;
Disinfectants/toxicity;
Extracorporeal Membrane Oxygenation;
Female;
Humans;
*Humidifiers;
Lung/drug effects/pathology;
Lung Diseases, Interstitial/*chemically induced/pathology/*therapy;
*Lung Transplantation;
Republic of Korea;
Respiratory Rate;
Retrospective Studies;
Thorax/diagnostic imaging;
Tomography, X-Ray Computed
- From:Journal of Korean Medical Science
2016;31(5):817-821
- CountryRepublic of Korea
- Language:English
-
Abstract:
From 2006 to 2011, an outbreak of a particular type of childhood interstitial lung disease occurred in Korea. The condition was intractable and progressed to severe respiratory failure, with a high mortality rate. Moreover, in several familial cases, the disease affected young women and children simultaneously. Epidemiologic, animal, and post-interventional studies identified the cause as inhalation of humidifier disinfectants. Here, we report a 4-year-old girl who suffered from severe progressive respiratory failure. She could survive by 100 days of extracorporeal membrane oxygenation support and finally, underwent heart-lung transplantation. This is the first successful pediatric heart-lung transplantation carried out in Korea.
