Effectiveness of Loxoprofen Sodium on Nocturia in Patients with Benign Prostatic Hyperplasia.
10.4111/kju.2007.48.2.195
- Author:
Hyuk Soo CHANG
1
;
Byoung Kun KIM
;
Ji Choal SOHN
;
Choal Hee PARK
;
Chun Il KIM
Author Information
1. Department of Urology, Keimyung University School of Medicine, Daegu, Korea. cikim@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Benign prostatic hyperplasia;
Nocturia;
Anti-inflammatory agents, non-steroidal
- MeSH:
5-alpha Reductase Inhibitors;
Age Distribution;
Anti-Inflammatory Agents, Non-Steroidal;
Cholinergic Antagonists;
Edema;
Humans;
Hypnotics and Sedatives;
Leg;
Nocturia*;
Prostate;
Prostatic Hyperplasia*;
Rivers;
Sodium*
- From:Korean Journal of Urology
2007;48(2):195-198
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The effectiveness of Loxoprofen sodium, a non-steroidal anti-inflammatory drug (NSAID), on the nocturia in patients with benign prostatic hyperplasia (BPH), not responding to anticholinergics or hypnotics, as well as alpha-blockers and 5 alpha reductase inhibitors, were investigated. MATERIALS AND METHODS: Between October 2004 and June 2005, 150 BPH patients with 2 or more episodes of nocturia, despite treatments with anticholinergics or hypnotics, were enrolled in this study. Loxoprofen, 60mg/day, was orally administered prior to sleeping for 2 weeks. The number of episodes of nocturia was assessed before and after treatment according to baseline number of episodes of nocturia, age distribution, prostate volume and previous nocturia treatment. RESULTS: The number of nocturia episodes decreased by at least 1 in 74.7% (112/150) of patients, and decreased by 2 or more, 1 and were unchanged or increased were 48.0, 26.7 and 25.3% of patients, respectively. In baseline nocturia > or =6 group, the nocturia decreased by 1 or more in 85.0%. Treatment-emergent adverse events, including gastric discomfort (12 patients, 8.0%), weak urinary stream (5 patients, 3.3%) and leg edema (2 patients, 1.3%), occurred in 19 of the 150 (12.7%) patients. There were no withdrawals resulting from adverse events. CONCLISIONS: Loxoprofen can be effectively combined as a treatment option for patients with BPH complaining of unresolved nocturia. However, studies on the mechanism of action, long term effectiveness and adverse events of Loxoprofen are necessary.
