Advances in the relationship between insulin-like growth factor-1 and eye diseases
10.3980/j.issn.1672-5123.2025.11.18
- VernacularTitle:胰岛素样生长因子-1与眼病关系的研究进展
- Author:
Yue TENG
1
;
Hongsheng BI
1
;
Wenjun JIANG
1
Author Information
1. Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
insulin-like growth factor-1(IGF-1);
phosphatidylinositol-3-kinase(PI3K);
protein kinase B(AKT);
retinal diseases;
Graves' ophthalmopathy
- From:
International Eye Science
2025;25(11):1826-1832
- CountryChina
- Language:Chinese
-
Abstract:
Insulin-like growth factor-1(IGF-1)is a multifunctional growth factor which plays an important role in various physiological and pathological processes of the body by regulating biological behaviors such as cell proliferation, differentiation, and migration. Studies have found that abnormal expression of IGF-1 in the retina, sclera and other eye tissues can participate in the occurrence, development and prognosis of various ophthalmic diseases by regulating retinal autophagy flux and angiogenesis, adipogenic differentiation of orbital soft tissues and degradation of scleral extracellular matrix. This paper systematically integrates the expression level changes and mechanism of action of IGF-1 in ophthalmic diseases such as diabetic retinopathy(DR), age-related macular degeneration(ARMD), retinopathy of prematurity(ROP), Graves' ophthalmopathy, myopia, corneal injury and uveal melanoma(UM), and combines the latest clinical and animal experimental evidence to evaluate the bright prospects and potential risks of IGF-1 targeted therapy, in order to provide new ideas and theoretical basis for the prevention and treatment of ophthalmic diseases.
