Pathogenesis and Treatment Based on Syndrome Differentiation of Traditional Chinese Medicine for Cough Variant Asthma： A Review
10.13422/j.cnki.syfjx.20252023
- VernacularTitle:咳嗽变异性哮喘发病机制及中医药辨证论治研究进展
- Author:
Jingshu LUO
1
;
Mingxia YU
2
;
Mingsheng LYU
1
;
Hongsheng CUI
1
Author Information
1. Beijing University of Chinese Medicine Third Affiliated Hospital， Beijing 100029， China
2. Affiliated Hospital of Shandong University of Traditional Chinese Medicine， Jinan 250355， China
- Publication Type:Journal Article
- Keywords:
cough variant asthma;
pathogenesis;
traditional Chinese medicine;
syndrome differentiation and treatment;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(22):125-134
- CountryChina
- Language:Chinese
-
Abstract:
Cough variant asthma （CVA） is a special type of asthma and the most common cause of chronic cough in China. It has a relatively high incidence， seriously affects patients' quality of life， and in some cases may even progress to typical asthma， posing an important challenge in the field of health economics. At present， first-line treatment in Western medicine mainly consists of inhaled corticosteroids combined with bronchodilators. However， there remain many problems such as poor efficacy in some patients， frequent relapse after drug withdrawal， and poor compliance， making it urgent to improve treatment strategies. In-depth research on the pathogenesis is helpful for a comprehensive understanding and prevention of CVA. The pathogenesis of CVA is complex and involves multiple pathophysiological links. While similar to typical asthma， it still presents some differences. Traditional Chinese medicine （TCM） has unique advantages in the treatment of CVA. Guided by the theory of syndrome differentiation and treatment， TCM can not only improve the clinical symptoms of CVA but also prevent recurrence. In recent years， with the continuous deepening of research on the pathogenesis of CVA and on its treatment with TCM based on syndrome differentiation， related academic achievements have been updated year by year. A review of literature in China and abroad shows that the current pathogenesis of CVA can be summarized into six aspects： airway inflammation， airway remodeling， airway hyperresponsiveness， cough hypersensitivity， genetic factors， and imbalance of intestinal flora. TCM often differentiates and treats CVA from four perspectives： cause， disease location， disease nature， and disease tendency. This paper systematically summarizes the progress in the study of CVA pathogenesis， comprehensively collates the experience and clinical research evidence on its treatment with TCM based on syndrome differentiation， and discusses the problems existing in current research. On this basis， it puts forward suggestions and prospects for future research and development of TCM in the treatment of CVA， with a view to providing a theoretical basis and therapeutic approaches for its prevention and treatment.
