Platelet bacterial contamination in China: a meta-analysis
10.13303/j.cjbt.issn.1004-549x.2025.09.024
- VernacularTitle:我国血小板细菌污染情况的Meta分析
- Author:
Xiuyun LIAO
1
;
Yang HUANG
2
;
Yuan ZHANG
1
;
Miao HE
2
;
Zhan GAO
2
Author Information
1. Deyang Central Blood Station, Deyang 618000, China
2. Institute of Blood Transfusion, Chinese Academy of Medical Science & Peking Union Medical College, Chengdu 610052, China
- Publication Type:Journal Article
- Keywords:
platelet;
bacterial contamination;
meta-analysis;
blood donors
- From:
Chinese Journal of Blood Transfusion
2025;38(9):1272-1279
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the status and influencing factors of platelet bacterial contamination in China, and to provide theoretical support for relevant policies in blood collection and transfusion institutions. Methods: A meta-analysis by systematically searching studies on platelet bacterial contamination in China published between 1998 and 2023 was conducted. Data analysis was performed using R4.4 software to combine studies that met the inclusion criteria. Results: Twenty-three studies were included after screening. The combined analysis showed that the overall contamination rate of platelets in China was 0.18% (95% CI: 0.12%-0.24%). The contamination rate of manually condensed platelets was significantly higher than that of apheresis platelet concentrates (0.28% vs 0.17%, P<0.01). No significant difference in platelet contamination rates was found between eastern and central regions (0.21% vs 0.15%, P>0.01). The contamination rate of aerobic bacteria was higher than that of anaerobic bacteria (0.11% vs 0.06%, P<0.01). Publication bias analysis indicated robust results, and sensitivity analysis showed minimal impact of excluding individual studies on the overall conclusion. Conclusion: Although the platelet contamination rate in China is generally low, significant differences exist across collection methods and regions.
