Application of a digital chylous plasma assessment device in the determination of chylous plasma
10.13303/j.cjbt.issn.1004-549x.2025.09.018
- VernacularTitle:数字化乳糜血浆判定装置在乳糜血浆判定中的应用
- Author:
Lingyue GUO
1
;
Caina LI
1
;
Hongyan GAO
2
;
Wei WEI
1
;
Ping ZHANG
1
;
Yan LIU
1
;
Yajie WANG
1
;
Weidong HE
1
Author Information
1. Blood Center of Shandong Province, Jinan 250000, China
2. Dongying Traditional Chinese Medicine Hospital, Dongying 257055, China
- Publication Type:Journal Article
- Keywords:
blood bank;
digitalization;
chylous;
plasma;
determination
- From:
Chinese Journal of Blood Transfusion
2025;38(9):1236-1241
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To develop a simple digital chylous plasma device and validate its ability to accurately, standardly, and non-destructively determine chylous plasma in blood banks and clinical transfusions in hospitals. Methods: A digital chylous plasma assessment device was designed and manufactured. This device was used to measure the chylous degrees of chylous plasma samples before freezing, after freeze-thawing, before viral inactivation, and after viral inactivation. The measured chylosity index values were categorized according to the requirements specified in Appendix A of the Chinese national standard GB 18469-2001 "Quality Requirements for Whole Blood and Blood Components". This process established a digital standard for chylous plasma, enabling the identification of severe, moderate and mild chylous plasma, and non-chylous plasma. Results: The initial simple product of the digital chylous assessment device was successfully designed and manufactured. There was no significant difference in the degree of chylous plasma between pre-freezing 468.11±217.73 lux and post-thawing 538.91±273.39 lux of chylous plasma (P>0.05), or between pre-viral inactivation 858.33±387.79 lux and post-viral inactivation 928.33±166.51 lux of chylous plasma (P>0.05). The median of chylous degree values for plasma chylous index grades 0 to 6 were 45 lux, 250 lux, 620 lux, 835 lux, 1 130 lux, 1 390 lux, and 1 700 lux, respectively. The defined cutoff values/ranges for the chylous degree values corresponding to plasma chylous index grade 0 to 6 were ≤125 lux, 126-465 lux, 466-740 lux, 741-1 000 lux, 1 001-1 233 lux, 1 234-1 560 lux, and ≥1 561 lux. Conclusion: This study successfully developed the initial product of the digital chylous device and established digital standards for classifying chylous plasma. The device demonstrates the potential to meet the needs for assessment of chylous plasma in both blood banks and clinical transfusions in hospitals, thereby promoting the development and application of standardized, non-destructive chylous plasma assessment technology.
