Antibody threshold and demographic characteristics of low-titer group O whole blood donors in Jiangsu
10.13303/j.cjbt.issn.1004-549x.2025.09.016
- VernacularTitle:江苏地区低效价O型全血献血者抗体阈值及人群特征分析
- Author:
Tao FENG
1
;
Rui ZHU
1
;
Wenjia HU
1
;
Ling MA
1
;
Hong LIN
1
;
Xi YU
1
;
Chun ZHOU
1
;
Nizhen JIANG
1
Author Information
1. Jiangsu Blood Center, Nanjing 210042, China
- Publication Type:Journal Article
- Keywords:
Jiangsu;
whole blood donors;
low-titer group O whole blood (LTOWB);
threshold;
demographic characteristics
- From:
Chinese Journal of Blood Transfusion
2025;38(9):1225-1229
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the distribution of IgM anti-A/B titers among group O whole blood donors in Jiangsu, establish a low-titer threshold, and analyze the demographic characteristics of low-titer donors, so as to provide data for recruiting low-titer group O whole blood (LTOWB) donors. Methods: Plasma samples from 1 009 group O whole blood donors were tested for IgM anti-A and anti-B titers using the microplate technique. The distribution of antibody titers was analyzed to establish a low-titer threshold. The distribution trends of titers across different demographic groups were also analyzed. Results: The peak titer for anti-A, anti-B were 64 (31.5%), 4 (23.8%), respectively, The proportion of donors with both anti-A and anti-B titers below 64 was 97.3% (982/1 009). The mean anti-A titer was higher than anti-B titer. Anti-A titers were higher in female donors than in male donors (P<0.05). The anti-A titers differed significantly among different age groups (P<0.05). However, no significant difference in titers was observed based on the number of donations (P>0.05). Conclusion: A titer of 64 can be used as the reference threshold of LTOWB in Jiangsu. Male donors of appropriate age are more suitable than female donors for establishing an emergency panel of LTOWB mobile donors.
