Hormonal regulation of uterine chemokines and immune cells.
10.5653/cerm.2011.38.4.179
- Author:
Dong Wook PARK
1
;
Kwang Moon YANG
Author Information
1. Laboratory of Reproductive Biology and Infertility, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.
- Publication Type:Review
- Keywords:
Immunology;
Endometrium;
Immune tolerance;
Sex steroid hormone;
Inflammation;
Blastocyst;
Embryo;
Chemokine;
Implantation window;
Human
- MeSH:
Blastocyst;
Chemokines;
Dietary Sucrose;
Embryonic Structures;
Endometrium;
Female;
Humans;
Immune Tolerance;
Inflammation;
Menstrual Cycle;
Pregnancy;
Social Control, Formal;
Uterus
- From:Clinical and Experimental Reproductive Medicine
2011;38(4):179-185
- CountryRepublic of Korea
- Language:English
-
Abstract:
The ultimate function of the endometrium is to allow the implantation of a blastocyst and to support pregnancy. Cycles of tissue remodeling ensure that the endometrium is in a receptive state during the putative 'implantation window', the few days of each menstrual cycle when an appropriately developed blastocyst may be available to implant in the uterus. A successful pregnancy requires strict temporal regulation of maternal immune function to accommodate a semi-allogeneic embryo. To preparing immunological tolerance at the onset of implantation, tight temporal regulations are required between the immune and endocrine networks. This review will discuss about the action of steroid hormones on the human endometrium and particularly their role in regulating the inflammatory processes associated with endometrial receptivity.
