Relationship between serum visfatin, NLR and disease severity in elderly patients (≥90 years old) with coronary heart disease
10.3969/j.issn.1006-2483.2025.05.021
- VernacularTitle:血清内脏脂肪素、NLR水平与高龄（≥90岁）冠心病患者病情严重程度的关系
- Author:
Jianxia ZHANG
1
;
Junnong LI
1
;
Jianli GU
2
,
3
,
4
;
Dangjun QUAN
1
Author Information
1. Department of Cardiology , Weinan Central Hospital , Weinan , Shaanxi 714000 , China
2. Department of Pharmacy , Xi'
3. an Third Hospital , Xi'
4. an , Shaanxi 710021 , China
- Publication Type:Journal Article
- Keywords:
Visfatin;
Neutrophil-to-lymphocyte ratio;
Elderly;
Coronary heart disease;
Atherosclerosis degree
- From:
Journal of Public Health and Preventive Medicine
2025;36(5):93-96
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between serum visfatin, neutrophil-to-lymphocyte ratio (NLR) and disease severity of coronary heart disease (CHD) in elderly patients (≥90 years old). Methods One hundred and two elderly patients (≥90 years old) with CHD who received coronary CT angiography (CTA) were selected from January 2020 to June 2024. In addition, thirty-five elderly patients (≥90 years old) without CHD who underwent coronary CTA during the same period were included in the control group. The CHD patients were divided into mild group, moderate group and severe group by CT-SYNTAX score. The clinical data and levels of serum visfatin and NLR were compared, and the correlation and diagnostic value of the above levels with disease severity of CHD in elderly patients were analyzed. Results Serum visfatin and NLR were manifested as severe group>moderate group>mild group>control group (P<0.05). Pearson correlation analysis found that serum visfatin and NLR were moderately positively correlated with CT-SYNTAX score (r=0.574, 0.482, P<0.001). Receiver operating characteristics (ROC) curve indicated that the area under the curve (AUC) of combination of serum visfatin and NLR in diagnosing severe lesion in elderly patients (≥90 years old) with CHD was 0.882, which was higher than that of visfatin or NLR alone, and its 95%CI was 0.803-0.938. Conclusion There is a certain correlation between serum visfatin, NLR and disease severity of CHD in elderly patients. The combination of the above indicators has a higher predictive value on severe lesion.
