TCM Treatment of Lung Cancer Based on AMPK Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20250322
- VernacularTitle:基于AMPK信号通路探讨中医药治疗肺癌的研究进展
- Author:
Chengzhi WANG
1
;
Yifan LIU
1
;
Zhenyao YANG
1
;
Wenjun LI
1
;
Xiaoqing ZHANG
2
;
Dongdong LI
3
;
Peimin LIU
3
Author Information
1. Henan University of Chinese Medicine， Zhengzhou 450053， China
2. The First Affiliated Hospital of Zhengzhou University， Zhengzhou 450052， China
3. The Second Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450002， China
- Publication Type:Journal Article
- Keywords:
adenosine monophosphate-activated protein kinase （AMPK）;
signaling pathway;
traditional Chinese medicine;
lung cancer;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(21):291-298
- CountryChina
- Language:Chinese
-
Abstract:
As a common malignant tumor of the respiratory system， the incidence and mortality of lung cancer are still rising year by year. Its pathogenesis is complex， the prognosis is poor， and it seriously affects human physical and mental health. Although existing Western medical treatments can inhibit tumor growth to a certain extent and relieve patients' painful symptoms， problems such as postoperative recurrence and metastasis， numerous adverse reactions， and the tendency to develop drug resistance make the overall therapeutic effect unsatisfactory. Therefore， it is urgent to seek more efficient and safer treatments. Adenosine monophosphate-activated protein kinase （AMPK） signaling pathway can regulate the growth， differentiation， apoptosis， and autophagy of lung cancer cells， and is extensively involved in the occurrence and development of lung cancer， thus being regarded as an important target for anti-lung cancer therapy. Traditional Chinese medicine （TCM） exerts anti-lung cancer effects through multiple pathways， mechanisms， and targets， with advantages such as preventing postoperative recurrence and metastasis， alleviating the adverse reactions of radiotherapy and chemotherapy， and improving quality of life. TCM has therefore become a key approach in current anti-lung cancer treatment. Studies have found that active components of Chinese medicine， including flavonoids， saponins， polyphenols， and terpenes， as well as Chinese medicine compound prescriptions such as Guiqi Yiyuan extract， Qingzao Jiufei decoction， and Yiqi Fuzheng formula， have significant regulatory effects on AMPK and its interacting signaling pathways. These effects include inducing autophagy and apoptosis of lung cancer cells， modulating macrophage polarization， inhibiting epithelial-mesenchymal transition， reversing drug resistance， and blocking the cell cycle， thereby exerting anti-lung cancer activity. This article reviews and summarizes recent studies on the anti-lung cancer effects of TCM， and discusses the mechanisms by which TCM regulates the AMPK signaling pathway in the treatment of lung cancer， with the aim of providing ideas and references for the development of new clinical anti-lung cancer drugs.
