Historical Evolution and Modern Clinical Application of Huoxiang Zhengqisan
- VernacularTitle:藿香正气散的历史衍变与现代临床应用
- Author:
Weilu NIU
1
;
Mengjie YANG
2
;
Chengqi LYU
2
;
Cuicui SHEN
1
;
Congcong LI
3
;
Huangchao JIA
1
;
Liyun WANG
1
;
Xuewei LIU
1
;
Mingsan MIAO
3
;
Xiaomeng WANG
1
;
Yawei YAN
4
;
Chunyong LIU
5
Author Information
1. The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
2. The First Clinical Medical College of Henan University of Chinese Medicine，Zhengzhou 450046，China
3. Henan Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yuyao，Henan University of Chinese Medicine，Zhengzhou 450046，China
4. Henan Academy of Traditional Chinese Medicine，Zhengzhou 450000，China
5. Zhujiang Hospital of Southern Medical University，Guangzhou 510282，China
- Publication Type:Journal Article
- Keywords:
Huoxiang Zhengqisan;
key information;
modern applications;
textual research;
formula composition;
origin;
dosage;
clinical application
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(21):156-167
- CountryChina
- Language:Chinese
-
Abstract:
In this study， bibliometric methods were used to systematically investigate the name and origin， the evolution of prescription composition， dose evolution， origin and processing method， decoction method， ancient application， modified application， modern application and other information of Huoxiang Zhengqisan. After research， Huoxiang Zhengqisan， also known as Huoxiang Zhengqitang， was first recorded in Taiping Huimin Hejijufang. The original formula is composed of 41.3 g of Arecae Pericarpium， 41.3 g of Angelicae Dahuricae Radix， 41.3 g of Perilla frutescens（actually Perillae Folium）， 41.3 g of Poria， 82.6 g of Pinelliae Rhizoma， 82.6 g of Atractylodis Macrocephalae Rhizoma， 82.6 g of Citri Reticulatae Pericarpium（actually Citri Exocarpium Rubbum）， 82.6 g of Magnoliae Officinalis Cortex， 82.6 g of Platycodonis Radix， 123.9 g of Pogostemonis Herba， and 103.25 g of Glycyrrhizae Radix et Rhizoma. In this formula， Magnoliae Officinalis Cortex is processed according to the specifications for ginger-processed products， Glycyrrhizae Radix et Rhizoma is processed according to the specifications for stir-fried products， and other herbs are used in their raw products. The botanical sources of the herbs are consistent with the 2020 edition of Pharmacopoeia of the People's Republic of China. The above herbs are ground into a fine powder with a particle size passing through a No. 5 sieve. For each dose， take 8.26 g of the powdered formula， add 300 mL of water， along with 3 g of Zingiberis Rhizoma Recens and 3 g of Jujubae Fructus， and decoct until reduced to 140 mL. The decoction should be administered hot， with three times daily. To induce sweating， the patient should be kept warm under a quilt， and an additional dose should be prepared and taken if needed. This formula is traditionally used to relieve the exterior and resolve dampness， regulate Qi and harmonize the middle， which is mainly used to treat a series of diseases of digestive and respiratory systems. However， potential adverse reactions， including allergies， purpura and disulfiram-like reactions， should be considered during clinical use. Huoxiang Zhengqisan features a rational composition， extensive clinical application， and strong potential for further research and development.
