Application Value of 18F-FDG PET/CT Metabolic Parameters in Prognosis of Nasopharyngeal Carcinoma
10.3971/j.issn.1000-8578.2025.25.0107
- VernacularTitle:18F-FDG PET/CT代谢参数在鼻咽癌患者预后中的应用价值
- Author:
Shanshan HE
1
;
Nana LUO
1
;
Xiaoyan HU
1
;
Lei LI
1
;
Yin NI
1
;
Dasheng QIU
1
Author Information
1. PET/CT Center, Hubei Cancer Hospital Affiliated of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430079, China.
- Publication Type:CLINICALRESEARCH
- Keywords:
18F-FDG;
PET/CT;
Metabolic parameters;
Nasopharyngeal carcinoma;
Prognosis
- From:
Cancer Research on Prevention and Treatment
2025;52(9):741-746
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of 18F-FDG PET/CT metabolic parameters in the prognostic assessment of nasopharyngeal cancer patients. Methods The clinical data and PET/CT metabolic parameters of 185 nasopharyngeal cancer patients were retrospectively analyzed. The collected parameters were SUVmax, MTV, TLG, total metabolic tumor volume (TMTV) and whole-body total lesion glycolysis (WTLG). The ROC curve was used to determine the optimal cut-off values of PET/CT metabolic parameters. Univariate and multivariate Cox regression models were used to screen the independent prognostic factors. Kaplan–Meier curves were used to analyze the survival differences. Results The results of univariate Cox regression analysis showed that age, pathologic type, WTLG, TMTV, MTV, and TLG were closely associated with OS and PFS; and SUVmax was associated with PFS (P<0.05). Multivariate Cox regression analysis results showed that age, TMTV, and WTLG were the independent prognostic factors for OS and PFS (P<0.05). The combination of WTLG with T/N staging (AUC=0.781 and 0.781) and TMTV with T/N staging (AUC=0.800 and 0.790) yielded greater predictive accuracy than that of WTLG and TMTV alone (AUC=0.724 and 0.719) or T/N staging (AUC=0.593 and 0.575). Conclusion TMTV and WTLG are important prognostic predictors of nasopharyngeal carcinoma. TLG and MTV of primary lesions are prognostic factors for patients’ PFS and OS. SUVmax has limited prognostic value. Systemic metabolic indexes (TMTV and WTLG), when combined with T/N staging, can optimize prognostic stratification.
