Tryptophan metabolism and immune system
10.13200/j.cnki.cjb.004191
- VernacularTitle:色氨酸代谢与免疫系统
- Author:
WANG Xinyi
- Publication Type:Journal Article
- Keywords:
Tryptophan(Trp);
Kynurenine(Kyn);
Immune regulation;
Aryl hydrocarbon receptor(AhR)
- From:
Chinese Journal of Biologicals
2025;38(09):1117-1124
- CountryChina
- Language:Chinese
-
Abstract:
Tryptophan(Trp), an essential amino acid of mammals, is decomposed mainly through kynurenine pathway(KP)and 5-hydroxytryptamine(5-HT) pathway, and the rest were metabolized by intestinal flora. KP is the main pathway, which is co-initiated by the rate-limiting enzyme tryptophan 2,3-dioxygenase(TDO) and interferon-reactive indoleamine 2,3-dioxygenase(IDO). The Trp decomposition products produced through the above pathways play a key role in immune regulation and maintenance of intestinal homeostasis by binding with aryl hydrocarbon receptor(AhR). Based on current studies on Trp metabolism, this paper systematically discusses the relationship between Trp pathway and immune system, as well as focuses on intestinal immunity and new potential therapeutic targets.
