Research progress on universal influenza virus vaccines
10.13200/j.cnki.cjb.004555
- VernacularTitle:通用型流感病毒疫苗的研究进展
- Author:
ZHANG Xinming
- Publication Type:Journal Article
- Keywords:
Universal influenza virus vaccines;
Hemagglutinin(HA);
Conservative epitope;
Broad spectrum protection
- From:
Chinese Journal of Biologicals
2025;38(09):1111-1116
- CountryChina
- Language:Chinese
-
Abstract:
Influenza virus poses a constant threat to human health because of its high variability and seasonal epidemic characteristics. At present, seasonal influenza vaccines often do not match epidemic strains due to antigenic drift or antigenic shift because they target the highly varied hemagglutinin(HA) head domain of viruses, and the protective effect is limited. To solve this problem, researchers are committed to developing universal influenza vaccines, which can induce extensive immune protection by targeting virus conservative epitopes, such as HA stem, M2 ectodomain(M2e) and nucleoprotein(NP),and combining with new technology platforms, such as mRNA, nanoparticles and virus-like particles(VLPs). In this paper,the latest research progress on universal influenza virus vaccine is reviewed, including design strategies based on HA conservative epitopes[such as chimeric HA, mosaic HA and computationally optimized broadly reactive antigen(COBRA)],vaccines based on other viral proteins(such as NA, M2e, NP and M1) and the application of emerging technology platforms(such as mRNA vaccine and nanoparticle delivery system), in order to provide new ideas for the prevention and control of influenza virus.
