Progress on the mechanisms of prevention and treatment of radiation-induced intestinal injury using Chinese medicine monomers and application of nanotechnology for enhanced efficiency
10.13491/j.issn.1004-714X.2025.04.024
- VernacularTitle:中药单体防治放射性肠损伤机制及纳米技术增效应用研究进展
- Author:
Lei CHEN
1
;
Zekun LI
2
;
Chaoqun PI
1
;
Yang HE
1
;
Ming LI
2
Author Information
1. The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou 215006, China.
2. State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.
- Publication Type:ReviewArticles
- Keywords:
Radiation-induced intestinal injury;
Inflammatory cytokine inhibition;
Oxidative damage;
Traditional Chinese medicine monomer;
Nanomaterial
- From:
Chinese Journal of Radiological Health
2025;34(4):614-624
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced intestinal injury is caused by high dose of radiation in the abdomen and pelvis. The disease is characterized by complicated pathological mechanisms and poses significant challenges to clinical treatment, seriously affecting the quality of life and health of patients. Current treatments in modern medicine offer limited efficacy and are often associated with adverse side effects. Traditional Chinese medicine monomers inhibit inflammatory factors (e.g., tumor necrosis factor-α and interleukin-1β) and regulate the antioxidant enzyme system (e.g., improving the activity of superoxide dismutase) to effectively reduce the symptoms of radiation-induced intestinal injury with minimal side effects. Through targeted delivery of nanoparticles, nanotechnology can accurately deliver the active ingredients of traditional Chinese medicine to damaged intestinal tissues, thus improving their bioavailability and therapeutic effects. This paper reviews the mechanisms of Chinese medicine monomers in the prevention and treatment of radiation-induced intestinal injury and the application of nanotechnology for enhanced efficiency. The paper also discusses the clinical potential of these approaches. These results provide a reference for future research and clinical practice.
