Interpretation of "Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases"
- VernacularTitle:《非小细胞肺癌脑转移的单细胞和空间基因组景观》解读
- Author:
Shishi ZOU
1
,
2
;
Ruyuan HE
1
,
2
;
Guoqing LUO
1
,
2
;
Ning LI
1
,
2
;
Qing GENG
1
,
2
Author Information
1. Department of Thoracic Surgery, Wuhan University People&rsquo
2. s Hospital, Wuhan, 430060, P. R. China
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer;
brain metastases;
single-cell sequencing;
spatial transcriptomics
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2025;32(07):953-957
- CountryChina
- Language:Chinese
-
Abstract:
Non-small cell lung cancer is one of the primary types of cancer that leads to brain metastases. Approximately 10% of patients with non-small cell lung cancer have brain metastases at the time of diagnosis, and 26%-53% of patients develop brain metastases during the progression of their disease. However, the underlying mechanisms of lung cancer brain metastasis have not been fully elucidated. With the continuous development of single-cell and spatial transcriptomics, the genomic and transcriptomic characteristics of lung cancer brain metastasis are gradually being revealed. In February 2025, the journal Nature Medicine published an article titled "Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases". This article aims to provide a brief interpretation of the paper for colleagues in research and clinical practice.
