Research progress of decellularized extracellular matrix in the field of tissue engineering in thoracic and cardiac surgery
- VernacularTitle:脱细胞基质应用于胸心外科组织工程领域的研究进展
- Author:
Hao CHEN
1
;
Jianwei ZHU
1
;
Hongcan SHI
1
Author Information
1. 1. Northern Jiangsu People s Hospital Affiliated to Yangzhou University, Yangzhou, 225009, Jiangsu, P. R. China 2. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225009, Jiangsu, P. R. China 3. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou, 225009, Jiangsu, P. R. China
- Publication Type:Journal Article
- Keywords:
Tissue engineering;
extracellular matrix;
decellularization;
bioink;
review
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2025;32(06):863-868
- CountryChina
- Language:Chinese
-
Abstract:
The extracellular matrix provides a unique tissue-specific microenvironment for resident cells, supporting the essential functions required for tissue architecture and biochemical signaling. Decellularized extracellular matrix (dECM) is designed to eliminate cells that mediate immunological rejection while preserving the native tissue structure and matrix functionality. dECM has attracted significant attention in tissue engineering applications and has evolved into a novel and increasingly sophisticated biomaterial. This article summarizes representative protocols for decellularization methods, explores the latest applications of decellularized tissue-derived materials and bioinks in the field of cardiothoracic surgery, analyzes the current challenges and issues confronting dECM, and discusses future perspectives for its development.
