Influencing factors for recurrence after successful treatment in pulmonary tuberculosis patients with isoniazid resistance in Shaoxing City， Zhejiang Province
10.19428/j.cnki.sjpm.2025.25160
- VernacularTitle:浙江省绍兴市异烟肼耐药肺结核患者成功治疗后复发的影响因素
- Author:
Jiamei SUN
1
;
Laichao XU
1
;
Zuokai YANG
1
;
Huaqiang GAO
1
;
Kaixuan ZHANG
1
;
Qiaoling LU
1
;
Haibin MENG
1
Author Information
1. Shaoxing Center for Disease Prevention and Control, Shaoxing, Zhejiang 312075, China
- Publication Type:Journal Article
- Keywords:
pulmonay tuberculosis;
isoniazid resistance;
recurrence;
influencing factor
- From:
Shanghai Journal of Preventive Medicine
2025;37(7):616-619
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the influencing factors for recurrence in successfully treated pulmonary tuberculosis patients with isoniazid-resistant and rifampicin-sensitive in Shaoxing City, Zhejiang Province. MethodsData on general demographic information, treatment information and drug susceptibility test results for pulmonary tuberculosis patients admitted to the designated tuberculosis medical institutions and registered in the tuberculosis information management system was collected in Shaoxing City from January 2011 to August 2024. A total of 428 patients with isoniazid resistance (including isoniazid single resistance and multiple resistance) but who were successfully treated were included in the study. Information for the recurrence after successful treatment of the patients was analyzed. The Cox proportional hazards models were used to analyze the influencing factors of recurrence in patients. ResultsAmong the 428 successfully treated patients included in the study, 31 cases (accounting for 7.24%) had recurrence by the end of the observation period, with a recurrence rate density of 1.31 per 100 person-years and a median recurrence time of 0.99 (0.08, 8.27) years. Among the relapsed population, 51.61% of the patients relapsed within one year after successful treatment. 77.42% of the patients relapsed within two years after successful treatment. Multivariate Cox regression analysis showed that when isoniazid resistance was discovered, the diagnosis classification of relapse (HR=4.115, 95%CI: 1.734‒9.767) and positive 0-month sequence smear (HR=4.457, 95%CI: 1.053‒18.866) were risk factors for recurrence after successful treatment in patients. ConclusionRegular follow-up should be strengthened for at least two years after the successful treatment of isoniazid-resistant pulmonary tuberculosis patients. Special attention should be paid to the treatment effect and regular re-examination and monitoring after the end of the treatment course of isoniazid-resistant pulmonary tuberculosis patients who have been re-treated and were sputum smear positive at baseline, so as to prevent recurrence and disease progression in high-risk populations.
