A cohort study of lipid levels and recurrence risk of ischemic stroke in a community-based natural population in Songjiang District， Shanghai
10.19428/j.cnki.sjpm.2025.24813
- VernacularTitle:上海市松江区社区自然人群血脂水平与缺血性脑卒中复发风险的队列研究
- Author:
Yangbo GENG
1
;
Huayuan FEI
2
;
Yunlong KAN
3
;
Minhua TANG
3
;
Yunhui WANG
4
;
Jianguo YU
5
;
Jiedong XU
6
;
Yiling WU
3
;
Genming ZHAO
1
;
Yonggen JIANG
3
;
Yan JIN
5
Author Information
1. School of Public Health,Fudan University, Shanghai 200032, China
2. Songjiang District Sheshan Community Health Service Center, Shanghai 201600, China
3. Songjiang District Center for Disease Control and Prevention, Shanghai 201600, China
4. Songjiang District Xinqiao Community Health Service Center, Shanghai 201600, China
5. Songjiang District Zhongshan Community Health Service Center, Shanghai 201600, China
6. Songjiang District Maogang Community Health Service Center, Shanghai 201600, China
- Publication Type:Journal Article
- Keywords:
community;
cohort study;
ischemic stroke;
plasma lipid;
recurrence
- From:
Shanghai Journal of Preventive Medicine
2025;37(7):562-568
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the recurrence of ischemic stroke (IS) and to analyze the association between four indices of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) and the risk of IS recurrence by analyzing the follow-up data related to IS in the community-based natural population of Songjiang District, Shanghai, so as to provide a scientific basis for improving the prognosis of stroke patients in the community and controlling IS recurrence. MethodsA prospective follow-up study was conducted among the IS patients in the community-based cohort population, collecting data about patient’s age, gender, disease history, biochemical indicators, and etc. Cox regression model and restricted cubic spline model were used to analyze the relationship between different levels of plasma lipids and the recurrence of IS in these patients. ResultsA total of 1 368 patients with IS were included. The total follow-up duration was 7 171.46 person-years, with a median follow-up time of 6.24 years. There were 420 cases of IS recurrence, resulting in a cumulative recurrence rate of 30.70%. The results of multivariate Cox regression analysis showed that the recurrence risk of IS was reduced when the baseline TC and LDL-C levels of IS patients were in the ranges of 4.65‒5.67 mmol·L-1 and 2.52‒3.46 mmol·L-1, respectively. The results of restricted cubic spline analysis showed a U-shaped relationship between baseline TC and LDL-C levels and the recurrence risk in IS patients. ConclusionThe cumulative recurrence rate of patients with IS in the community of Songjiang District in Shanghai is high, and the levels of TC and LDL-C at baseline survey are correlated with the recurrence of IS in these patients. It is suggested to pay more attention to the levels of LDL-C and TC in patients with IS, so as to improve the prognosis.
