Coptidis Rhizoma and Its Prescriptions in Treatment of Diabetic Cognitive Impairment： A Review
10.13422/j.cnki.syfjx.20251192
- VernacularTitle:黄连及其方剂配伍防治糖尿病认知障碍研究进展
- Author:
Tianyi REN
1
;
Yun LING
2
;
Yiming SHEN
1
;
Hui FENG
2
Author Information
1. The First Clinical Medical College，Nanjing University of Chinese Medicine，The First School of Clinical Medicine，Nanjing 210023，China
2. School of Chinese Medicine，Nanjing University of Chinese Medicine，Nanjing 210023，China
- Publication Type:Journal Article
- Keywords:
Coptidis Rhizoma;
impressive;
diabetic cognitive impairment;
prescription compatibility;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(20):266-275
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cognitive impairment （DCI） has an insidious onset and progressive and irreversible development. There is currently no first-line treatment for DCI. Early intervention of diabetes with traditional Chinese medicine （TCM） can effectively control blood sugar and improve cognitive impairment， which has significant advantages. As a representative of bitter and cold heat-clearing medicines， Coptidis Rhizoma， known for its abilities to clear heat and dampness and remove turbidity and toxins， has been widely used in the clinical prevention and treatment of diabetes， Alzheimer's disease， vascular dementia， and other cognitive impairments. This article systematically summarized relevant literature and observed that Coptidis Rhizoma has shown good potential in the prevention and treatment of DCI with its active ingredients such as berberine and quercetin， drug pairs such as Coptidis Rhizoma-Scutellariae Radix， Coptidis Rhizoma-Acorus Tatarinowii Rhizoma， Coptidis Rhizoma-Pinelliae Rhizoma， Coptidis Rhizoma-Zingiberis Rhizoma， and prescriptions such as Gegen Qinliantang， Huanglian Jiedutang， Banxia Xiexintang， Huanglian Wendantang， Jiaotai Wan， Danggui liuhuangtang， and related Chinese patent medicines. Its mechanism may be related to regulating glucose metabolism， improving insulin resistance， improving amyloid β-protein （Aβ） deposition and tau protein phosphorylation， inhibiting neuroinflammation and oxidative stress， and regulating the "microbe-gut-brain axis". The article systematically reviewed the research progress of Coptidis Rhizoma and its prescriptions in the prevention and treatment of DCI， aiming to preliminarily explain the scientific connotation of Coptidis Rhizoma and provide a basis for its clinical application in the prevention and treatment of DCI.
