Compilation Instructions for Expert Consensus on Clinical Application of Dieda Huoxue Capsules
10.13422/j.cnki.syfjx.20252294
- VernacularTitle:《跌打活血胶囊临床应用专家共识》编制说明
- Author:
Yuhang MENG
1
;
Jinghua GAO
2
;
Minshan FENG
2
;
Quan JI
3
;
Jin JIN
4
;
Ting CHENG
2
;
Yongyao LI
2
;
Yuanyuan LI
1
;
Xin CUI
1
;
Yanming XIE
1
Author Information
1. Institute of Basic Research in Clinical Medicine，China Academy of Chinese Medical Sciences，Beijing 100700，China
2. Wangjing Hospital，China Academy of Chinese Medical Sciences，Beijing 100102，China
3. Beijing Hospital，Beijing 100005，China
4. Peking Union Medical College Hospital，Beijing 100006，China
- Publication Type:Journal Article
- Keywords:
Dieda Huoxue capsules;
expert consensus;
compilation instructions;
clinical application
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(20):177-183
- CountryChina
- Language:Chinese
-
Abstract:
The Compilation Instructions for Expert Consensus on Clinical Application of Dieda Huoxue capsules systematically expound the development methods and evidence-based basis of this consensus. In view of the weak clinical application evidence and ambiguous indications of Dieda Huoxue capsules， the Institute of Basic Research in Clinical Medicine of the China Academy of Chinese Medical Sciences and Wangjing Hospital took the lead and collaborated with 33 experts from 28 medical institutions nationwide. They strictly followed the World Health Organization （WHO） guideline-making norms and the Grading of Recommendations Assessment， Development and Evaluations （GRADE） evidence-grading system and completed the compilation through multidisciplinary cooperation. The workflow included constructing clinical questions （19 items were screened by the nominal group technique）， retrieving evidence （from Chinese and English databases and grey literature）， assessing safety （integrating drug monitoring data and clinical investigations）， and forming recommendations and consensus suggestions （3 recommendations were reached via the GRADE grid method， and 16 consensus suggestions were reached by the majority vote rule）. The results indicate that the consensus clearly states that this medicine （Dieda Huoxue capsules） is applicable to conditions like traumatic injury， blood stasis-induced pain， and sudden lumbar sprains. The recommended dose is 6 capsules each time， twice a day. Combining oral administration with external application can enhance the efficacy， and elderly patients should take the medicine at intervals. Safety monitoring suggests that it should be used with caution in people with a bleeding tendency and those with an allergic constitution. The compilation process involved three rounds of reviews by internal and external experts. Literature analysis， the Delphi method， and clinical applicability tests were employed to ensure methodological rigor. The compilation instructions comprehensively present key aspects such as project approval and registration， conflict-of-interest statements， and evidence evaluation through 12 appendices， providing methodological support for the clinical translation of the consensus. In the future， it will be continuously improved through a dynamic revision mechanism.
