Changes in the levels of miR-34a and miR-29b in lens epithelial cells of patients with age-related cataract and their clinical significance
10.3980/j.issn.1672-5123.2025.10.28
- VernacularTitle:年龄相关性白内障患者晶状体上皮细胞中miR-34a及miR-29b水平变化及临床意义
- Author:
Ling ZHENG
1
,
2
;
Haibo JIANG
1
,
2
;
Mengru LI
1
,
2
;
Bo ZHOU
1
,
2
Author Information
1. Suizhou Hospital Affiliated to Hubei University of Medicine
2. Suizhou Central Hospital, Suizhou 441300, Hubei Province, China
- Publication Type:Journal Article
- Keywords:
age-related cataracts;
lens epithelial cells;
microRNA-34a(miR-34a);
microRNA-29b(miR-29b)
- From:
International Eye Science
2025;25(10):1704-1707
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the changes of microRNA-34a(miR-34a)and microRNA-29b(miR-29b)levels in lens epithelial cells of age-related cataracts(ARC)patients and their clinical significance.METHODS: A total of 65 ARC patients(study group)and 53 cases of clear lens anterior capsulorhexis(control group)who visited our hospital from February 2023 to February 2024 were gathered. Pearson was applied to test the correlation between miR-34a and miR-29b. Multifactor Logistic regression was applied to determine the factors affecting the occurrence of ARC.RESULTS: Compared with the control group, the expression levels of miR-34a and miR-29b in lens epithelial cells of the research group showed a significant decrease trend(all P<0.05). There was a positive correlation between miR-34a and miR-29b in the lens epithelial cells of ARC patients(r=0.472, P<0.05). MiR-34a and miR-29b were influence factors for ARC(all P<0.05).CONCLUSION: The levels of miR-34a and miR-29b in lens epithelial cells of ARC patients are significantly reduced, which is associated with the occurrence of ARC.
