Role of the high-sensitivity C-reactive protein in the pathogenesis and progression of diabetic retinopathy
10.3980/j.issn.1672-5123.2025.10.26
- VernacularTitle:高敏C反应蛋白在糖尿病视网膜病变发生发展中的作用
- Author:
Jingnan LIU
1
;
Hanyu WU
1
;
Xiaosi CHEN
1
;
Yiyun ZENG
1
;
Linghui PI
1
;
Xinyuan ZHANG
1
;
Xinyuan ZHANG
1
Author Information
1. Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
- Publication Type:Journal Article
- Keywords:
high-sensitivity C-reactive protein;
diabetic retinopathy;
pathogenesis;
predictor;
risk factor
- From:
International Eye Science
2025;25(10):1694-1698
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the role of serum high-sensitivity C-reactive protein(hsCRP)in the pathogenesis and progression of diabetic retinopathy(DR)in patients with type 2 diabetes mellitus(T2DM).METHODS:A nested case-control study was conducted involving 187 T2DM patients(187 eyes)who attended at Eye Center, Beijing Tongren Hospital, Capital Medical University from June 2017 to October 2024. Patients were categorized into three groups: the diabetes mellitus(DM)group, non-proliferative DR(NPDR)group, and proliferative DR(PDR)group. Baseline information was collected, including age, sex, duration of DM, and duration of hypertension. All patients underwent fasting biochemical tests and comprehensive ophthalmic examinations.RESULTS: A positive correlation was observed between hsCRP and fasting blood glucose(FBG; P=0.004)and glycated hemoglobin A1c(HbA1c; P=0.048)by Spearman's rank correlation coefficient analysis. After adjusting for confounding factors, multivariable Logistic regression identified hsCRP as a significant risk factor for DR(OR=2.67, 95% CI: 1.19-5.96, P=0.017). CONCLUSION:Serum hsCRP is positively correlated with FBG and HbA1c and can serve as an important predictor of the severity of DR.
