Mechanism of retinal injury caused by hyperglycemia, hypertension and hyperlipidemia
10.3980/j.issn.1672-5123.2025.10.15
- VernacularTitle:高血糖和高血压及高血脂对视网膜的损伤机制
- Author:
Shunting GUAN
1
,
2
;
Ping YU
1
,
2
Author Information
1. Qinghai University, Xining 810000, Qinghai Province, China
2. Department of Ophthalmology, Qinghai University Affiliated Hospital, Xining 810000, Qinghai Province, China
- Publication Type:Journal Article
- Keywords:
hyperglycemia;
hypertension;
hyperlipidemia;
retinopathy;
oxidative stress;
inflammatory factors;
vascular endothelial growth factor;
mechanism;
review
- From:
International Eye Science
2025;25(10):1635-1640
- CountryChina
- Language:Chinese
-
Abstract:
Retinopathy mainly arises from abnormalities in retinal blood vessels and nerves. Patients may experience symptoms such as decreased vision and visual field deletion, and are often treated with methods such as drugs,surgery, and laser. Previous studies have shown that hyperglycemia, hypertension, and hyperlipidemia can all cause retinal injury, and the three produce a synergistic pathological effect(multi-factor interaction leading to multiplied injury)to accelerate retinopathy. Exploring the additional aspects of mechanism of the three on the retina and exploring potential therapeutic targets have extremely critical clinical value for the early prevention and control of retinopathy and improvement of symptoms. The article summarizes the mechanisms by which the three lead to retinopathy, provides a theoretical basis for the development of multi-target combined therapy of vascular endothelial growth factor(VEGF)inhibitor, antioxidants and anti-inflammatory drugs, which not only helps early intervention and precise treatment, but also lays a foundation for the development of new drugs and individualized treatment strategies, and is of great significance for the prevention and treatment of metabolic eye diseases.
