Advances in the role of ketone body metabolism in the pathogenesis of diabetic retinopathy
10.3980/j.issn.1672-5123.2025.10.13
- VernacularTitle:酮体代谢在糖尿病视网膜病变发病机制中的作用研究进展
- Author:
Jiaxin LI
1
,
2
,
3
;
Yuanyuan ZHANG
1
,
2
,
3
;
Yan SHAO
1
,
2
,
3
Author Information
1. Tianjin Medical University Eye Hospital
2. Eye Institute, Tianjin Medical University
3. Tianjin Clinical Medical Research Centre for Eye Diseases, Tianjin 300384, China
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
ketone body metabolism;
oxidative stress;
inflammation;
neuropathy
- From:
International Eye Science
2025;25(10):1623-1627
- CountryChina
- Language:Chinese
-
Abstract:
Ketone body metabolism plays a significant role in the development and progression of diabetic retinopathy(DR), which closely related to the system and local metabolic disorders as a major microvascular complication of diabetes mellitus. Previous research has established a close relationship between dyslipidemia and DR progression. Ketone bodies, comprising β-hydroxybutyrate, acetoacetate, and acetone, are metabolic products generated from fat breakdown when glucose metabolism is impaired. Studies have revealed that ketone body metabolism is intricately linked to multiple pathophysiological processes in DR, including oxidative stress, inflammatory responses, and neurodegeneration within retinal cells. This article provides a review exploring the impact of ketone body metabolism on the pathogenesis of DR, and systematically reviews the latest research progress on the impact of ketone bodies on the core pathological links such as retinal vascular barrier destruction, glial cell activation and angiogenesis through metabolic reprogramming, epigenetic modification and cell signal transduction, so as to provide a theoretical basis for in-depth understanding of the metabolic driving mechanism of DR.
