Research progress on the regulation of diabetic retinopathy by the mTOR-autophagy pathway
10.3980/j.issn.1672-5123.2025.10.12
- VernacularTitle:mTOR-自噬途径调控糖尿病视网膜病变的研究进展
- Author:
Tingting QIN
1
,
2
,
3
;
Leying ZHANG
1
,
2
,
3
;
Ting LI
1
,
2
,
3
;
Xiaohui KUANG
1
,
2
,
3
;
Jiaojiao WANG
1
,
2
,
3
;
Zongming SONG
1
,
2
,
3
Author Information
1. Henan Medical University, Xinxiang 453003, Henan Province, China
2. Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China
3. Henan Eye Hospital, Zhengzhou 450003, Henan Province, China
- Publication Type:Journal Article
- Keywords:
mechanistic target of rapamycin(mTOR);
autophagy;
diabetic retinopathy;
dual roles
- From:
International Eye Science
2025;25(10):1617-1622
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy(DR)is one of the most common and severe microvascular complications in diabetic patients and has become one of the leading causes of blindness worldwide. With the continuous rise in the prevalence of diabetes, in-depth exploration of the pathogenesis of DR and effective intervention measures is of great clinical significance. The mechanistic target of rapamycin(mTOR), as a protein kinase, is widely involved in cellular processes such as growth, metabolism, and autophagy. Research indicates that the mTOR signaling pathway plays a crucial regulatory role in the pathological progression of DR, and its abnormal activity can disrupt retinal cell autophagy function, thereby accelerating cellular damage and disease progression. Autophagy, as an important regulatory mechanism for cellular homeostasis, maintains cellular functional balance by clearing damaged organelles and protein aggregates. This article provides a systematic review of the structural and functional aspects of the mTOR signaling pathway, the molecular regulatory mechanisms of autophagy, and their roles in retinal pathological changes. By summarizing current research findings, the article aims to clarify the key regulatory role of the mTOR-autophagy axis in DR, providing theoretical support for elucidating the molecular pathogenesis of DR and offering potential targets and research directions for developing novel targeted therapeutic strategies, thereby holding significant scientific and clinical value.
