Mechanisms and research progress of ferroptosis in glaucoma
10.3980/j.issn.1672-5123.2025.10.08
- VernacularTitle:铁死亡在青光眼中的作用机制及研究进展
- Author:
Feiyang XU
1
,
2
,
3
;
Fan XU
1
,
2
,
3
Author Information
1. Guilin Medical University, Guilin 541004, Guangxi Zhuang Autonomous Region, China
2. Guangxi Academy of Medical Sciences
3. the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, China
- Publication Type:Journal Article
- Keywords:
ferroptosis;
glaucoma;
oxidative stress;
lipid peroxidation;
optic nerve injury
- From:
International Eye Science
2025;25(10):1592-1597
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis, an iron-dependent form of programmed cell death characterized by lipid peroxidation, oxidative stress, and dysregulated iron metabolism, plays a significant role in the pathogenesis of glaucoma. This review systematically summarizes the fundamental mechanisms of ferroptosis, the involvement of oxidative stress and ferroptosis in glaucoma, the relationship between ferroptosis and glaucomatous neurodegeneration, and the potential therapeutic strategies targeting ferroptosis in glaucoma. Studies have shown that ferroptosis-regulating factors play a crucial role in mitigating oxidative damage and preserving cellular function. However, the complexity of their regulatory mechanisms not only hinders a comprehensive understanding of their roles but also impedes clinical translation. Although ferroptosis inhibitors have demonstrated promising neuroprotective effects in animal models, their clinical application remains challenged by issues such as drug safety and target specificity. Therefore, the development of more targeted and low-toxicity therapeutic strategies is essential to advance personalized and precise treatment for glaucoma.
