The causal relationship between neuroticism and gastroesophageal reflux disease: A bidirectional Mendelian randomization study in the European population
- VernacularTitle:针对欧洲人群神经质与胃食管反流病因果关系的双向孟德尔随机化研究
- Author:
Siding ZHOU
1
;
Hongbi XIAO
1
;
Mingjun GAO
2
;
Mengmeng WANG
2
;
Xiaolin WANG
3
,
4
;
Yusheng SHU
3
,
4
Author Information
1. Department of Medical College, Yangzhou University, Yangzhou, 225000, Jiangsu, P. R. China
2. Department of Dalian Medical University, Dalian, 116000, Liaoning, P. R. China
3. Department of Thoracic Surgery, Northern Jiangsu People'
4. s Hospital, Clinical Medical College of Yangzhou University, Yangzhou, 225000, Jiangsu, P. R. China
- Publication Type:Journal Article
- Keywords:
Neuroticism;
gastroesophageal reflux disease;
causal relationship;
Mendelian randomization
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2025;32(06):814-818
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between neuroticism and gastroesophageal reflux disease (GERD) using the Mendelian randomization (MR) method. Methods Exposure and outcome data were downloaded from the Integrative Epidemiology Unit (IEU) database in August 2023, including summary statistics from genome-wide association studies (GWAS) for neuroticism (n=374 323) and GERD (n=602 604). MR was conducted using the weighted median method, MR-Egger method, inverse variance weighted method, weighted mode method, and simple mode method. The causal relationship between the two was assessed using odds ratio (OR), and sensitivity analyses were performed to ensure the accuracy of the results. Results Neuroticism was associated with an increased risk of GERD [OR=1.229, 95%CI (1.186, 1.274), P<0.001]. Similarly, GERD was associated with an increased risk of neuroticism [OR=1.786, 95%CI (1.623, 1.965), P<0.001]. Conclusion There is a bidirectional causal relationship between neuroticism and gastroesophageal reflux disease.
