Pharmacological effects and drug design research progress of fucoxanthin
- VernacularTitle:岩藻黄素的药理作用及药物设计研究进展
- Author:
Yuxin ZHANG
1
;
Ziyang DENG
2
;
Can WANG
1
;
Dan ZENG
3
Author Information
1. College of Materials Science and Engineering，Chongqing University，Chongqing 400043，China
2. West China School of Pharmacy，Sichuan University，Chengdu 610207，China
3. Allergy Department，Chongqing People’s Hospital Affiliated to Chongqing University/Chongqing General Hospital，Chongqing 401121，China
- Publication Type:Journal Article
- Keywords:
fucoxanthin;
pharmacological effects;
drug design;
functional groups;
research progress
- From:
China Pharmacy
2025;36(17):2216-2220
- CountryChina
- Language:Chinese
-
Abstract:
Fucoxanthin is a pigment found in plants and animals such as algae， marine plankton and aquatic shellfish， and holds significant potential for development in the pharmaceutical field. This review introduces the anti-inflammatory， antioxidant， anticancer， anti-obesity， and other pharmacological effects of fucoxanthin， as well as recent advances in drug design research. It was found that fucoxanthin can exert anti-inflammatory and antioxidant effects through mechanisms such as activating AMP- activated protein kinase related signaling pathways， regulating the expression of inflammatory factors， altering microbial stability， thereby improving conditions such as metabolic associated fatty liver disease and colitis. It can exert selective antitumor effects through multi-target synergistic actions； and it was also found that it can exert anti-obesity effects by regulating the intestinal microbiota. Its characteristic functional groups （such as hydroxyl and epoxy groups） possess target specificity and reversible inhibitory properties， making it a suitable template for guiding the design and development of novel drugs， thereby providing new insights for breaking through the limitations of traditional drug design.
