Research progress on the pathological mechanisms and therapeutic strategies of chemotherapy-induced intestinal mucositis
- VernacularTitle:化疗所致肠黏膜炎的病理机制和治疗策略研究进展
- Author:
Xiaochen YAN
1
;
Zongkui WANG
1
;
Shengliang YE
1
Author Information
1. Institute of Blood Transfusion，Chinese Academy of Medical Sciences，Chengdu 610052，China
- Publication Type:Journal Article
- Keywords:
intestinal mucositis;
chemotherapy;
pathological mechanisms;
therapeutic strategies;
research progress
- From:
China Pharmacy
2025;36(17):2211-2215
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal mucositis is a common complication induced by chemotherapy in malignant tumors， which severely compromises the efficacy of chemotherapy and reduces patients’ quality of life. This article systematically reviews the pathological mechanisms underlying chemotherapy-induced intestinal mucositis， encompassing oxidative damage， inflammatory injury， apoptotic damage， disruption of the intestinal barrier， and intestinal dysbiosis. Additionally， it provides a comprehensive summary of current therapeutic strategies for intestinal mucositis， including chemical agents and composite materials， natural products， compound prescription of traditional Chinese medicine， growth factors， blood products， and fecal microbiota transplantation. Future efforts should strengthen multidisciplinary cross-innovation， integrating animal models and large-scale clinical trials to develop highly effective and low-toxicity therapeutic drugs that balance chemotherapy toxicity and antitumor efficacy.
