Progress on active components and mechanisms of Traditional Chinese Medicine in the prevention and treatment of acute lung injury
10.12206/j.issn.2097-2024.202404079
- VernacularTitle:中药防治急性肺损伤的活性成分及其作用机制研究进展
- Author:
Zixuan ZHANG
1
;
Yuan GAO
2
,
3
;
Li ZHANG
3
;
Jiali LI
3
;
Xike XU
1
;
Xianpeng ZU
1
Author Information
1. Basic Medicine School.
2. Basic Medicine School
3. School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
- Publication Type:Reviews
- Keywords:
acute lung injury;
active ingredients;
Traditional Chinese Medicine compound;
mechanism of action
- From:
Journal of Pharmaceutical Practice and Service
2025;43(9):421-426
- CountryChina
- Language:Chinese
-
Abstract:
Acute lung injury （ALI） refers to the rapid onset of dyspnea, hypoxemia, and diffuse alveolar damage induced by various direct and indirect injurious factors, representing one of the clinically common diseases with a high mortality rate. However, there is currently a lack of specific therapeutic interventions targeting their underlying pathological mechanisms. Western medical treatment primarily relies on supportive care, and the existing pharmacological agents for ALI are predominantly corticosteroids, which, while efficacious, often accompany severe adverse effects. Recent research has revealed that numerous active components in Traditional Chinese Medicine （TCM） exhibit remarkable efficacy in the prevention and treatment of ALI, providing new insights into the therapeutic approaches for ALI. In this article, the pathological mechanisms of ALI and the roles and mechanisms of active components from TCM in the prevention and treatment of ALI were reviewed, aiming to provide a theoretical basis for the development of new drugs for the prevention and treatment of ALI.
