Meta analysis of maternal overweight/obesity during pregnancy and offspring metabolic dysfunction associated steatotic liver disease
10.16835/j.cnki.1000-9817.2025259
- VernacularTitle:妊娠期超重肥胖和子代代谢相关脂肪性肝病的Meta分析
- Author:
WU Yuying, ENKAER Nuer, WANG Youxin, WANG Mingyue, YANG Yifan, YANG Shuhan, SUN Lingling, WANG Hui
1
Author Information
1. Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China
- Publication Type:Journal Article
- Keywords:
Pregnancy;
Overweight;
Obesity;
Fatty liver;
Meta analysis
- From:
Chinese Journal of School Health
2025;46(8):1079-1083
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluates the association between maternal overweight/obesity during pregnancy and offspring risk of metabolic dysfunction associated steatotic liver disease (MASLD), providing theoretical evidence for early life MASLD prevention.
Methods:An online search was conducted across ten databases (CNKI, Wanfang, SinoMed, PubMed, Embase, Web of Science, Cochrane Library, PROSPERO, PQDT Global, ScienceDirect) for research literature on the association between maternal overweight/obesity during pregnancy and the development of MASLD in offspring, with the search period spanning from January 2014 to December 2024. Two researchers independently screened literature, extracted data, and assessed study quality. Statistical analysis was performed using R 4.3.3.
Results:Ten studies involving 10 229 participants were included, comprising 4 cohort studies and 6 case control studies. Cohort studies showed that maternal overweight and obesity significantly increased offspring MASLD risk ( RR=1.59, 95%CI=1.06-2.39, P <0.05), with moderate heterogeneity ( I 2=56.9%, P =0.07). Case control studies indicated a positive association between maternal overweight/obesity during pregnancy and offspring risk of MASLD( OR=2.00, 95%CI=1.68-2.39, P < 0.05), with low heterogeneity ( I 2=48.8%, P =0.08).
Conclusions:Maternal overweight/obesity during pregnancy positively correlates with offspring MASLD risk. Gestational weight management may reduce the risk.
