Research Advances in Immunometabolism in Acute Myeloid Leukemia
10.3971/j.issn.1000-8578.2025.24.1328
- VernacularTitle:免疫代谢在急性髓系白血病中的研究进展
- Author:
Jiayi YAO
1
;
Zizhen XU
1
Author Information
1. College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
- Publication Type:REVIEWS
- Keywords:
Immunometabolism;
Acute myeloid leukaemia;
Haematological cancer;
Tumor microenvironment;
Immunotherapy
- From:
Cancer Research on Prevention and Treatment
2025;52(8):725-730
- CountryChina
- Language:Chinese
-
Abstract:
Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy characterized by an abnormal proliferation of primitive and naive myeloid cells in the bone marrow and peripheral blood. Patients vary enormously in molecular biological features, clinical manifestations and prognosis, leading to therapeutic difficulties. Increasing evidence indicates that the tumor microenvironment plays an important role in the development and progression of AML. Immunometabolism reveals the metabolic network of immune cells, which has important implications in tumor research. This work reviews the research progress on the metabolic alterations of immune cells in the AML microenvironment and the therapeutic strategies targeting immune metabolism in AML to present a part of the blueprint of immune metabolism regulation in the bone marrow microenvironment of AML.
