Research Advances on Cancer-Associated Fibroblasts in Tumor Prevention and Treatment
10.3971/j.issn.1000-8578.2025.24.1301
- VernacularTitle:肿瘤相关成纤维细胞在肿瘤预防和治疗中的研究进展
- Author:
Shanzhao WANG
1
;
Ruici YANG
2
;
Weiren HUANG
3
,
4
Author Information
1. Graduate School, Guangxi University of Chinese Medicine, Nanning 530200, China.
2. Shenzhen Key Laboratory of Synthetic Genomics, Guangdong Provincial Key Laboratory of Synthetic Genomics, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
3. Graduate School, Guangxi University of Chinese Medicine, Nanning 530200, China
4. Institute of Translational Medicine, The Second People’s Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University, Shenzhen 518025, China.
- Publication Type:REVIEWS
- Keywords:
Cancer-associated fibroblasts;
Tumor prevention;
Tumor treatment
- From:
Cancer Research on Prevention and Treatment
2025;52(8):717-724
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of solid tumors rely on the autonomous drive of tumor cells and the crosstalk of the tumor microenvironment (TME). As a crucial component of the TME, cancer-associated fibroblasts (CAFs) are the center of the cross-communication among various cells in the tumor stroma and participate in tumorigenesis, progression, invasion, and migration. Hence, targeting CAF subpopulations or their functional pathways might offer a new breakthrough for tumor prevention and treatment. However, the concurrent tumor-promoting and tumor-suppressive functions of CAFs pose an impediment to this breakthrough. By summarizing CAFs role in tumor occurrence and progression, this review proposes the application of CAFs in tumor prevention and treatment and discusses their potential and value as a therapeutic target.
