Medication Rules of Professor Hua Baojin in Treatment of Subsolid Pulmonary Nodules Based on Data Mining
10.3971/j.issn.1000-8578.2025.25.0051
- VernacularTitle:基于数据挖掘探析花宝金教授治疗亚实性肺结节的用药规律
- Author:
Huibo YU
1
,
2
;
Yue LI
2
;
Yue LUO
1
,
2
;
Hongyuan LIU
2
;
Xiyuan ZHANG
2
;
Jiaqi HU
2
;
Rui LIU
2
;
Baojin HUA
2
Author Information
1. Graduate School of Beijing University of Chinese Medicine, Beijing 100029, China
2. Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
- Publication Type:CLINICALRESEARCH
- Keywords:
Subsolid pulmonary nodule;
Data mining;
Medication rule;
Regulating qi and detoxifying;
Hua Baojin
- From:
Cancer Research on Prevention and Treatment
2025;52(8):682-691
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the medication rules of Professor Hua Baojin in the treatment of subsolid pulmonary nodules through retrospective analysis and data mining techniques. Methods The prescriptions of patients with subsolid pulmonary nodules who were diagnosed and treated by Professor Hua Baojin at Guang’anmen Hospital of the Chinese Academy of Chinese Medical Sciences from January 1, 2021 to December 31, 2024 were retrospectively collected. Data were imported into the Ancient and Modern Medical Case Cloud Platform for analysis of drug frequency, four natures and five flavors, meridian tropism, drug association, and hierarchical clustering. Results A total of 455 prescriptions were included, containing 205 kinds of traditional Chinese medicines, with a total frequency of 12048 times. Fifty-seven commonly used drugs were screened out, among which drugs with high frequencies included astragalus membranaceus (raw) and hawthorn fruit (charred). The nature of the drugs was mainly warm, cold, and neutral. The flavor of the drugs was mostly sweet, bitter, and pungent. The meridians they belonged to mainly included the lung, spleen, and liver meridians. Their efficacy was mainly tonifying deficiency, clearing heat, resolving phlegm, and relieving cough and asthma. Association analysis obtained 19 pairs of drug combinations, 21 groups of three-drug combinations, and four groups of four-drug combinations. Hierarchical clustering obtained 10 groups of drug combinations. Conclusion On the basis of the core pathogenesis of subsolid pulmonary nodule, Professor Hua applies the theory of regulating qi and detoxifying; regulating the qi of the liver, spleen, and lung; and detoxifying the toxins of phlegm and blood stasis, providing valuable experience for the clinical treatment of SSN.
