Relationship Between Gastroesophageal Reflux Disease-Related Symptoms and Clinicopathologic Characteristics and Long-Term Survival of Patients with Esophageal Adenocarcinoma in China

Kan ZHONG; Xin SONG; Ran WANG; Mengxia WEI; Xueke ZHAO; Lei MA; Quanxiao XU; Jianwei KU; Lingling LEI; Wenli HAN; Ruihua XU; Jin HUANG; Zongmin FAN; Xuena HAN; Wei GUO; Xianzeng WANG; Fuqiang QIN; Aili LI; Hong LUO; Bei LI; Lidong WANG

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Relationship Between Gastroesophageal Reflux Disease-Related Symptoms and Clinicopathologic Characteristics and Long-Term Survival of Patients with Esophageal Adenocarcinoma in China

VernacularTitle:胃食管反流病相关症状与中国食管腺癌患者临床病理特征及长期生存的关系
Author: Kan ZHONG ¹ ; Xin SONG ¹ ; Ran WANG ¹ ; Mengxia WEI ¹ ; Xueke ZHAO ¹ ; Lei MA ² ; Quanxiao XU ² ; Jianwei KU ³ ; Lingling LEI ¹ ; Wenli HAN ¹ ; Ruihua XU ¹ ; Jin HUANG ¹ ; Zongmin FAN ¹ ; Xuena HAN ¹ ; Wei GUO ⁴ ; Xianzeng WANG ⁵ ; Fuqiang QIN ⁶ ; Aili LI ⁶ ; Hong LUO ⁷ ; Bei LI ¹ ; Lidong WANG ¹
Author Information

1. Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention and Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
2. Henan Provincial Key Laboratory of Tumor Molecular Biology Medicine, Nanyang First People′s Hospital, Nanyang 473000, China.
3. Department of Oncology, The Third Affiliated Hospital of Nanyang Medical College, Nanyang 473000, China.
4. Department of Pathology, Linzhou People′s Hospital, Linzhou 456500, China.
5. Department of Thoracic Surgery, Linzhou People′s Hospital, Linzhou 456500, China.
6. Department of Oncology, Linzhou Cancer Hospital, Linzhou 456500, China.
7. Department of General Surgery, Guangshan People′s Hospital, Guangshan 465450, China.
Publication Type:SPECIALFEATURE
Keywords: Gastroesophageal reflux disease; Symptom; Esophageal adenocarcinoma; Clinicopathologic characteristic; Long-term survival
From: Cancer Research on Prevention and Treatment 2025;52(8):661-665
CountryChina
Language:Chinese
Abstract: Objective To investigatethe relationship between gastroesophageal reflux disease (GERD) symptoms and clinicopathological characteristics, p53 expression, and survival of Chinese patients with esophageal adenocarcinoma. Methods A total of 3882 patients with esophageal adenocarcinoma, 970 matched patients with esophageal squamous cell carcinoma, and 970 matched patients with gastric cardia adenocarcinoma were included to compare the incidence of GERD symptoms. Patients with esophageal adenocarcinoma were divided into two groups according to the presence and absence of GERD symptoms. The differences in clinicopathological characteristics and p53 expression between the two groups were compared by chi-square test, and the differences in survival between the two groups were compared by landmark analysis. Results The incidence of GERD symptoms increased successively in esophageal squamous cell carcinoma, esophageal adenocarcinoma, and gastric cardia adenocarcinoma. In patients with esophageal adenocarcinoma, the proportions of male, less than 65 years old, lower thoracic tumors, tumors without squamous cell carcinoma, poorly differentiation, early tumors (stage 0-I), and p53-positive tumors in the group with GERD symptoms were higher than those in the group without GERD symptoms; moreover, the long-term survival (≥15 years) was better. Conclusion GERD symptom is an important clinical sign of esophageal adenocarcinoma. It is closely related to specific clinicopathological characteristics, p53 overexpression, and good long-term prognosis.