Prospective Study of Disease Occurrence Spectrum in Asymptomatic Residents in Areas with High Incidence of Esophageal Cancer: 16-year Observation of 711 Cases in Natural Population

Qide BAO; Fangzhou DAI; Xueke ZHAO; Jingjing WANG; Xin SONG; Zongmin FAN; Yanfang ZHANG; Zhuo YANG; Junfang GUO; Kan ZHONG; Qiang ZHANG; Junqing LIU; Min LIU; Lidong WANG

Return

Prospective Study of Disease Occurrence Spectrum in Asymptomatic Residents in Areas with High Incidence of Esophageal Cancer: 16-year Observation of 711 Cases in Natural Population

VernacularTitle:食管癌高发区无症状居民疾病发生谱前瞻性研究——711例自然人群16年观察
Author: Qide BAO ¹ ; Fangzhou DAI ¹ ; Xueke ZHAO ² ; Jingjing WANG ¹ ; Xin SONG ² ; Zongmin FAN ² ; Yanfang ZHANG ¹ ; Zhuo YANG ¹ ; Junfang GUO ¹ ; Kan ZHONG ² ; Qiang ZHANG ¹ ; Junqing LIU ¹ ; Min LIU ¹ ; Lidong WANG ²
Author Information

1. Department of Oncology, Anyang District Hospital, Anyang 455000, China.
2. Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Publication Type:SPECIALFEATURE
Keywords: Esophageal carcinoma; High-incidence area; Disease occurrence spectrum; Endoscopic screening; Mucosal biopsy; Prospective study
From: Cancer Research on Prevention and Treatment 2025;52(8):656-660
CountryChina
Language:Chinese
Abstract: Objective To understand the disease spectrum of a natural village in an area with high incidence of esophageal cancer to provide a reference for precise prevention and control. Methods From 2008 to 2024, 711 asymptomatic people over the age of 35 years in a natural village with high incidence of esophageal cancer in China were surveyed, and 171 of them were subjected to gastroscopy, biopsy, and pathological examination. All participants were followed up for a long time, and their disease history was recorded. Results A total of 16 years of follow-up were performed, and 703 people were effectively followed up. In 2008, 171 people underwent gastroscopy, and 160 people had biopsy and pathological results in endoscopic screening. By 2024, 76 people had been diagnosed with malignant tumors of 12 different types, and among these people, 45 had esophageal cancer. Conclusion Esophageal cancer remains a significant cause of morbidity and mortality from malignant tumors in this region. Biopsy and pathological examination should be strengthened during gastroscopy, and follow-ups and regular check-ups should be given high importance to reduce the incidence and mortality rates of esophageal cancer.