Common Environmental Problems and Testing Experiences in Laboratory Animal Facilities in Sichuan Province
10.12300/j.issn.1674-5817.2024.142
- VernacularTitle:四川省实验动物设施常见环境问题及检测经验
- Author:
Wentao LIU
1
;
Yanhong LUO
2
;
Yongxia LONG
2
;
Qihui LUO
1
;
Zhengli CHEN
1
;
Lida LIU
3
Author Information
1. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
2. Sichuan Barrier Detection Technology Co., Ltd., Chengdu 611135, China
3. Sichuan Provincial Center for Disease Control and Prevention, Chengdu 610044, China
- Publication Type:Journal Article
- Keywords:
Sichuan Province;
Laboratory animals;
Laboratory animal facilities;
Environmental testing
- From:
Laboratory Animal and Comparative Medicine
2025;45(4):483-489
- CountryChina
- Language:Chinese
-
Abstract:
Laboratory animals are the "living" tools of medical research. Through animal experiments, people can gain continuous insights into the laws of life, reveal the essence of diseases, develop vaccines and drugs for prevention and treatment, and play an important role in the technological development of fields related to human health. The environmental conditions of laboratory animals have a direct impact on their health, quality, and the results of animal experiments. The higher the degree of environmental control, the more reliable the experimental results are in terms of quality. Therefore, environmental control of laboratory animal facilities is important for ensuring that laboratory animals live under required conditions, which is a key factor for conducting effective animal experiments. This article analyzes the current status of environmental testing of laboratory animal facilities in Sichuan Province, briefly summarizing their number, area, and other basic information, and provides detailed statistics on the ability of institutions to conduct environmental testing for laboratory animal facilities in Sichuan Province. It also summarizes the testing requirements for laboratory animal facility environments based on national standards, regulatory requirements, and the quality control needs of facility users. In the analysis of testing indicators for laboratory animal facilities, based on testing data from 40 laboratory animal facilities in Sichuan Province, it was found that static pressure difference is the indicator most prone to non-compliance, followed by illumination and air exchange rate. Using barrier environments as examples, common problems in the process of environmental testing for laboratory animal facilities are summarized in six aspects: testing personnel, instruments, methods, technical materials, testing environment, and reports, and targeted suggestions are proposed. These suggestions help improve environmental control in laboratory animal facilities, and provide practical reference and guidance for relevant testing institutions, as well as laboratory animal producers and users in the industry.
