Progress and Evaluation of Animal Model of Heart Qi-Yin Deficiency Syndrome
10.12300/j.issn.1674-5817.2024.176
- VernacularTitle:心气阴两虚证动物模型的构建方法与评价进展
- Author:
Yayi LIU
1
;
Yunfeng JIA
1
;
Yiming ZUO
1
;
Junping ZHANG
1
;
Shichao LÜ
1
Author Information
1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
- Publication Type:Journal Article
- Keywords:
Cardiovascular disease;
Qi-yin deficiency syndrome;
Animal models;
Combination of disease and syndrome
- From:
Laboratory Animal and Comparative Medicine
2025;45(4):411-421
- CountryChina
- Language:Chinese
-
Abstract:
Animal models combining disease and syndrome are important research tools to explore the nature of traditional Chinese medicine (TCM) syndromes. At present, the construction and evaluation methods of animal models have preliminarily established the foundation for standardized development. Qi-yin deficiency syndrome is a common type of TCM syndrome in cardiovascular diseases. It is an important pathogenic factor causing the onset, pathological damage, and chronic nature of cardiovascular diseases, as well as triggering other illnesses. The establishment of an animal model of cardiovascular disease with the characteristics of Qi-yin deficiency, along with an objective and standardized evaluation system, has become an important part of modern cardiovascular disease research. In recent years, research on the construction and evaluation of animal models of heart Qi-yin deficiency syndrome has increased, but the construction methods and evaluation criteria vary. Compared with other animal models, the literature is limited, lacking statistics and overall analysis. Therefore, based on the scientific connotation of heart Qi-yin deficiency syndrome, this article systematically reviews the evaluation system of its animal model, covering multidimensional methods such as macroscopic characterization assessment, physicochemical indicators and objective evaluation, and syndrome differentiation based on prescriptions. The specific model construction strategies are described, including single-factor induction methods (sleep deprivation, chronic intermittent hypoxia, arterial occlusion, high-salt feeding) and the compound-factor induction methods (sleep deprivation combined with drug method, chronic intermittent hypoxia combined with drug method, exhaustive swimming combined with drug method). Meanwhile, application examples of each model in the research are listed, the existing problems in the current model construction and evaluation are analyzed, and optimization directions are proposed, such as promoting the compound factor induction strategy and improving the objectivity of the evaluation criteria. This article aims to provide theoretical references for constructing an animal model of heart Qi-yin deficiency syndrome that conforms to TCM characteristics, and thereby laying a scientific foundation for the prevention and treatment of cardiovascular diseases with TCM.
