Detection and clinical analysis of drug-induced antibodies related to β-lactam antibiotics
10.13303/j.cjbt.issn.1004-549x.2025.07.009
- VernacularTitle:β-内酰胺类抗生素相关的药物性抗体检测及临床分析
- Author:
Yangyang ZHENG
1
;
Rongpeng WANG
2
;
Jie ZHAO
3
;
Bingzheng ZHUO
1
;
Feng CHEN
1
Author Information
1. Department of Clinical Transfusion, Inner Mongolia People's Hospital, Hohhot 010017, China
2. Department of Transfusion, Tongliao People's Hospital, Tongliao 028000, China
3. Department of Laboratory Medicine, Taiyuan Central Hospital, Taiyuan 030000, China
- Publication Type:Journal Article
- Keywords:
drug-induced antibodies;
β-lactam antibiotics;
anemia;
drug-induced immunohemolytic anemia
- From:
Chinese Journal of Blood Transfusion
2025;38(7):922-927
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the positive rate of drug-induced antibodies produced by the clinical application of β-lactam antibiotics, and analyze the differences in the detection methods and related influencing factors. Methods: A total of 350 adult inpatients who developed anemia after using β-lactam antibiotics for 3 days or more in Inner Mongolia People's hospital were selected as the experimental group, and 240 adult inpatients treated with β-lactam antibiotics for 3 days or more who did not develop anemia as the control group. The drug-induced antibody tests, direct antiglobulin tests, and unexpected antibody screening were performed on both groups, and the influencing factors of drug-induced antibodies were analyzed. Results: The numbers of positive cases of drug-induced antibody detected by the drug-coated red blood cell method in the experimental group and the control group were 12(12/350, 3.43%) and 2(2/240, 0.83%) respectively, with statistically significant differences (P<0.05). No drug-induced antibodies were detected in either group using the drug addition method. In the experimental group, the red blood cell method detected β-lactam drug-induced antibodies in 12 cases (12/350, 3.43%), while the drug added method detected 0 cases (0/350, 0.00%), with statistically significant differences (P<0.05). In the control group, the detection rates of two methods showed no statistically significant difference (P>0.05). In the experimental group, 7 cases of β-lactam antibodies were detected in the cephalosporin group (7/293, 2.40%) and 5 cases in the non-cephalosporin group (5/58, 8.62%), with statistically significant differences (P<0.05). There was no statistically significant difference between the second-generation and third-generation cephalosporin drugs (P>0.05). When the experimental group was stratified according to the history of blood transfusion and the blood type of patients, no statistically significant differences were observed between subgroups (P>0.05). Conclusion: Anemia may be related to the production of drug-induced antibodies followingβ-lactam antibiotics treatment. Therefore, improving the clinical awareness of drug-induced antibodies to β-lactam antibiotics is of great significance to clarify the causes of anemia and reduce unnecessary blood transfusions.
