Analysis of prognosis and influencing factors of sepsis patients receiving blood component transfusion
10.13303/j.cjbt.issn.1004-549x.2025.07.003
- VernacularTitle:血液成分输注对脓毒血症患者预后的影响因素分析
- Author:
Bingjie ZHAO
1
,
2
;
Bowei CAO
1
;
Yuanpei ZHU
1
;
Ningjie ZHANG
1
Author Information
1. Department of Blood Transfusion, Second Xiangya Hospital, Central South University, Changsha 410000, China
2. Department of Histology and Embryology, Basic School of Medicine Sciences, Central South University, Changsha 410000, China
- Publication Type:Journal Article
- Keywords:
sepsis;
blood component transfusion;
prognosis influence
- From:
Chinese Journal of Blood Transfusion
2025;38(7):879-885
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To identify influencing factors associated with the prognosis of sepsis patients receiving blood component transfusion, and to provide a more rational and scientific transfusion strategy for clinical management. Methods: Clinical data of 232 patients with sepsis treated at the Second Xiangya Hospital of Central South University between January 2022 and December 2023 were retrospectively analyzed. These patients were categorized into the transfusion group (n=64) and the non-transfusion group (n=168) based on whether they received transfusions, and the patients in the transfusion group were further divided into non-survivor group (n=26) and survivor group (n=38) based on their survival outcome. Baseline characteristics and clinical characteristics were compared between two groups. Factors impacting the prognosis of sepsis patients undergoing blood component transfusion were identified using logistic regression. Results: Compared to the non-transfusion group, the transfusion group showed significantly higher levels of coagulation indicators (prothrombin time, activated partial thromboplastin time, international normalized ratio, D-dimer) and inflammatory markers (C-reactive protein, procalcitonin, interleukin-6), while the level of hemoglobin, platelet, lymphocyte, fibrinogen, albumin, blood glucose, and oxygen saturation were significantly lower (P<0.05). The [M(P
, P
)] for C-reactive protein (mg/L), hemoglobin (g/L), and platelet count (×10
/L) in the transfusion vs non-transfusion groups were 178.0(156.1-178) vs 102.7(74.0-119.6), 88.5(72.3-113.0) vs 110.5(101-121.8), and 63.0(26.5-156.5) vs 202.5(108.3-286.8), respectively (all P<0.05). Logistic regression analysis revealed that hemoglobin level, platelet count, lactate concentration, and the storage duration of transfused red blood cells were independent risk factors affecting the survival outcomes of sepsis patients receiving transfusions (P<0.05). In septic transfusion patients, the [M(P
, P
)] lactate concentration (mmol/L) and RBC storage time (d) in the non-survivor vs survivor groups were 3.5(1.9-7.7) vs 2.1(1.3-3.5), 18.0 (13.0-18.0) vs 12.0(9.0-14.0), respectively (both P<0.05). Conclusion: Compared to non-transfused sepsis patients, those receiving transfusions exhibited poorer baseline conditions, more severe infections, and worse survival outcomes. More importantly, the study found that the timing of transfusion decisions and the quality control of blood products (such as storage duration) may directly impact patient prognosis, providing critical evidence for optimizing transfusion strategies in septicemia patients.
